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| 男科 | 妇科 | 骨科 | 耳鼻喉 | 肛肠 | 泌尿 | 不孕不育 | 皮肤病 | 口腔 | 肿瘤 | 糖尿病 | 眼病 | 性病 | 肝病 | 心血管 | 更多 |
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乳腺癌检测的新标志p130Cas
注意阅读时间，健康用眼！ 2013-12-14 中医诊疗网 www.zlnow.com
目录号：MS-855
小鼠单克隆抗体（克隆号 CAS-14）
应用
* 对常规的经福尔马林处理的和石蜡包埋的组织进行免疫组化染色
* Western Blotting
* 免疫沉淀
生物学背景
p130 Cas是一种130kDa的docking蛋白，含于不同的生物学步骤中：
* Cell Adhesion
* Cell Proliferation
* Cell Migration
* Possibly Oncogenic Transformation
激素治疗乳腺癌的Tamoxifen-A
Tamoxifen（三苯氧胺），是一种选择性雌激素受体调节器（SERM）。它是目前应用最广泛的内分泌治疗法，适用于各个阶段的激素引起的乳腺癌的治疗。
尽管不能提高由雌激素受体(-)和黄体酮受体(-)引起的肿瘤的存活率，但Tamoxifen可以提高在乳癌ER(+)早期阶段的病人的无复发和完全存活率。
p130 Cas在乳腺癌中的Prognostic Value
在处于乳腺癌ER(+)早期阶段的病人体内，高p130 Cas水平与下列因素有关：
* 低无复发和完全存活率
* 疾病迅速复发
* 抗Tamoxifen的高风险性
相关产品价目表：
| 目录号 | 产品说明 | 规格 | 价格(元) |
| MS-855P0 | p130 Cas Ab-1(Purified Ab with BSA and Azide) | 0.1ml | 700 |
| MS-855P1 | p130 Cas Ab-1(Purified Ab with BSA and Azide) | 0.5ml | 2926 |
| MS-855P | p130 Cas Ab-1(Purified Ab with BSA and Azide) | 1ml | 4466 |
| MS-855P1ABX | p130 Cas Ab-1(Purified Ab without BSA and Azide) | 100μl | 3346 |
| MS-855PABX | p130 Cas Ab-1(Purified Ab without BSA and Azide) | 200μl | 4886 |
| MS-855R7 | p130 Cas Ab-1(7.0ml Ready for Histology) | 7ml | 3206 |
| MS-855PCL | p130 Cas Ab-1(Positive Control for Histology) | 100μl | 980 |
| MS-855PCS | p130 Cas Ab-1(Positive Control for Western Blot) | 5slides | 840 |
| MS-855B0 | p130 Cas Ab-1(Biotin-Labeled Ab with BSA and Azide) | 0.1ml | 1400 |
| MS-855B | p130 Cas Ab-1(Biotin-Labeled Ab with BSA and Azide) | 0.5ml | 5726 |
| MS-855B1 | p130 Cas Ab-1(Biotin-Labeled Ab with BSA and Azide) | 1ml | 3766 |
| MS-855F0 | p130 Cas Ab-1(FITC-Labeled Ab with BSA and Azide) | 0.1ml | 1400 |
| MS-855F | p130 Cas Ab-1(FITC-Labeled Ab with BSA and Azide) | 0.5ml | 5726 |
| MS-855F1 | p130 Cas Ab-1(FITC-Labeled Ab with BSA and Azide) | 1ml | 3766 |
| MS-855PE0 | p130 Cas Ab-1(PE-Labeled Ab with BSA and Azide) | 0.1ml | 1400 |
| MS-855PE | p130 Cas Ab-1(PE-Labeled Ab with BSA and Azide) | 0.5ml | 5726 |
| MS-855PE1 | p130 Cas Ab-1(PE-Labeled Ab with BSA and Azide) | 1ml | 3766 |
参考文献：
1. O'Regan RM, Gradishar WJ: Selective Estrogen-Receptor Modulators in 2001. Oncology 2001 Sep; 15(9): 1178-85, 1189-90, 1190-4
2. Muss HB: Role of Adjuvant Endocrine Therapy in Early-Stage Breast Cancer. Semin Oncol 2001 Aug;28(4): 313-21
3. Brinkman A, van der Flier S, Kok EM, Dorssers LC: BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells. J Natl Cancer Inst 2000 Jan 19; 92(2): 112-20
4. van der Flier S, Brinkman A, Look MP, Kok EM, Meijer-van Gelder ME, Klijn JG, Dorssers LC, Foekens JA: Bcar1/p130Cas protein and primary breast cancer: prognosis and response to tamoxifen treatment. J Natl Cancer Inst 2000 Jan 19; 92(2): 120-7
